Yu S.-F.CHIA-TUNG SHUNChen T.-M.YEN-HUI CHEN2021-03-182021-03-1820060918-6158https://scholars.lib.ntu.edu.tw/handle/123456789/553243The young sticks and leaves of Sauropus androgynus (SA) that had been used as a health food for body weight reduction, led to an outbreak of obliterative bronchiolitis in Taiwan. This study tested the toxicity and anti-obesity features of the SA-isolated compound, 3-O-β-D-glucosyl-(1→6)-β-D- glucosyl-kaempferol (GGK), on male Wistar rats receiving 6 or 60 mg/kg of GGK orally as well as partial purified EtOAc and n-BuOH fractions of SA extract daily for 28 d. Sixty milligrams per kilogram GGK treatment significantly reduced food intake in rats by 15% (p<0.05). The reduced food intake corresponded to decreases in body weight in the high or low dose GGK groups, as compared to the control groups. The serum levels of free triglyceride significantly decreased in GGK-treated rats. GGK treatment led to succesive reductions in daily food intake and body weight without obvious histopathological changes in Wistar rats. Thus, GGK may be potentially to be developed as a safe and novel compound for anti-obesity treatment. ? 2006 Pharmaceutical Society of Japan.[SDGs]SDG33 o beta dextro glucosyl (1-6) beta dextro glucosyl kaempferol; acetic acid ethyl ester; butanol; pioglitazone; plant extract; sauropus androgenus extract; triacylglycerol; animal experiment; animal model; animal tissue; article; controlled study; dose response; drug isolation; drug megadose; Euphorbia; food intake; histopathology; low drug dose; male; nonhuman; obesity; plant leaf; rat; rat strain; triacylglycerol blood level; weight gain; weight reduction; Animals; Body Weight; Disaccharides; Dose-Response Relationship, Drug; Euphorbiaceae; Kaempferols; Liver; Lung; Male; Rats; Rats, Wistar; Weight Gainjournal article10.1248/bpb.29.2510171429922-s2.0-33845359254