Yang, C.-H.C.-H.YangHsieh, Y.-L.Y.-L.HsiehPING-HSIEN TSOULi, B.-R.B.-R.Li2020-04-272020-04-2720191932-6203https://scholars.lib.ntu.edu.tw/handle/123456789/485792Blood tests provide crucial diagnostic information regarding several diseases. A key factor that affects the precision and accuracy of blood tests is the interference of red blood cells; however, the conventional methods of blood separation are often complicated and time consuming. In this study, we devised a simple but high-efficiency blood separation system on a self-strained microfluidic device that separates 99.7 ± 0.3% of the plasma in only 6 min. Parameters, such as flow rate, design of the filter trench, and the relative positions of the filter trench and channel, were optimized through microscopic monitoring. Moreover, this air-difference-driven device uses a cost-effective and easy-to-use heater device that creates a low-pressure environment in the microchannel within minutes. With the aforementioned advantages, this blood separation device could be another platform choice for point-of-care testing.en[SDGs]SDG3Article; blood sampling; controlled study; cost effectiveness analysis; equipment design; erythrocyte; flow rate; human; hypobarism; mathematical model; microfluidic analysis; nanofabrication; point of care testing; process design; suction; blood examination; devices; economics; lab on a chip; suction; thermodynamics; time factor; Equipment Design; Hematologic Tests; Humans; Lab-On-A-Chip Devices; Point-of-Care Testing; Suction; Thermodynamics; Time Factors7089384310.1371/journal.pone.0208676308452392-s2.0-85062621092WOS:000460638800003http://www.scopus.com/inward/record.url?eid=2-s2.0-85062621092&partnerID=MN8TOARS70893843