HSIN-HSI TSAIHORNG-HUEI LIOUMuo C.-H.RUOH-FANG YENLee, Cha-ZeCha-ZeLeeKao C.-H.2020-09-232020-09-2320160028-3878https://scholars.lib.ntu.edu.tw/handle/123456789/514446Objective: To determine whether hepatitis C virus (HCV) infection is a risk factor for developing Parkinson disease (PD). Methods: This nationwide population-based cohort study was based on data obtained from a dataset of the Taiwan National Health Insurance Research Database for the period 2000 to 2010. A total of 49,967 patients with viral hepatitis were included for analysis. Furthermore, 199,868 people without viral hepatitis were included for comparisons. Patients with viral hepatitis were further grouped into 3 cohorts: hepatitis B virus (HBV) infection, HCV infection, and HBV-HCV coinfection. In each cohort, we calculated the incidence of developing PD. A Cox proportional hazards model was applied to estimate the risk of developing PD in terms of hazard ratios (HRs) and 95% confidence intervals (CIs). Results: The crude HRs for developing PD was 0.66 (95% CI 0.55-0.80) for HBV infection, 2.50 (95% CI 2.07-3.02) for HCV infection, and 1.28 (95% CI 0.88-1.85) for HBV-HCV coinfection. The association between HCV and PD remained statistically significant after adjustments for age, sex, and comorbidities (adjusted HR 1.29, 95% CI 1.06-1.56). Conclusions: We conducted a large nationwide population-based study and found that patients with HCV exhibit a significantly increased risk of developing PD. ? 2016 American Academy of Neurology.[SDGs]SDG3adult; aged; Article; cerebrovascular accident; cohort analysis; comorbidity; controlled study; diabetes mellitus; disease association; epilepsy; female; follow up; head injury; hepatitis B; hepatitis C; human; hyperlipidemia; hypertension; ICD-9-CM; incidence; ischemic heart disease; liver cirrhosis; major clinical study; male; Parkinson disease; priority journal; risk assessment; age distribution; epidemiology; hepatitis C; middle aged; Parkinson disease; reproducibility; sensitivity and specificity; sex ratio; Taiwan; Adult; Age Distribution; Aged; Causality; Cohort Studies; Comorbidity; Female; Hepatitis C; Humans; Incidence; Male; Middle Aged; Parkinson Disease; Reproducibility of Results; Risk Assessment; Sensitivity and Specificity; Sex Distribution; Taiwanjournal article10.1212/WNL.0000000000002307267013822-s2.0-84959527095