Po-Chan WuWen-Yu WangPo-Ling KuoPO-LING KUO2019-10-312019-10-312014https://scholars.lib.ntu.edu.tw/handle/123456789/429291T-cells play a central role in many physiological and pathological conditions such as cytotoxicity of cancer cells. An effective recruitment of T-cells in these conditions requires a prompt migration of T-cells from vascular trees to the pathological targets. However, the effects of increased fluid pressure on T-cell motility and other activities such as cytotoxicity of cancer cells have been barely addressed. In the present study, we demonstrated microfluidic-based platforms that have potential in studying the effects of hydrostatic pressure on the motility of T-cells and the effects of applying pressures on the T-cell mediated cytotoxicity of cancer cells. ? 14CBMS.Cancer cell; Cell migration; Coculture; Hydrostatic pressure; Microfluidic; T cell[SDGs]SDG3Cell death; Cytology; Cytotoxicity; Diseases; Hydraulics; Hydrostatic pressure; Microfluidics; T-cells; Applying pressure; Cancer cells; Cell migration; Coculture; Fluid pressures; Microfluidic-based; Pathological conditions; Vascular trees; Cellsconference paper2-s2.0-84941642942