Su W.W.-Y.Chuang S.-L.Yen A.M.-F.Chen S.L.-S.Fann J.C.-Y.Chiu S.Y.-H.HAN-MO CHIUSu C.-W.Hsu C.-Y.Chen M.-K.Chen, Tony Hsiu HsiTony Hsiu HsiChenCHENG-PING WANGYI-CHIA LEE2020-11-032020-11-0320191354-523Xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85063519898&doi=10.1111%2fodi.13080&partnerID=40&md5=4a5e2853410d217073ec2efd2ad9bf06https://scholars.lib.ntu.edu.tw/handle/123456789/520266Objective: To investigate the risk for second primary cancer in the hypopharynx and esophagus (SPC-HE) among individuals with an initial oral/oropharyngeal cancer. Materials and Methods: Mass screening data from Taiwan (2004–2009) included individuals who were ?18?years old and smoked cigarettes and/or chewed betel quid. Occurrence of SPC-HE was monitored until December 31, 2014. Results were expressed as adjusted relative risk (aRR) and 95% confidence interval (CI). Results: One hundred and fifty-eight out of 4,494 subjects with oral cancer developed SPC-HE (incidence rate: 6.47 per 1,000 person-years). Relative to patients with primary cancers in the lip, the risk of an SPC-HE was higher in patients with primary cancers in oropharynx (aRR: 19.98, 95% CI: 4.72–84.55), floor of mouth (aRR: 12.13, 95% CI: 2.67–55.15), and hard palate (aRR: 7.31, 95% CI: 1.65–32.37), but not in patients with cancers in tongue (aRR: 3.67, 95% CI: 0.89–15.17) or gum (aRR: 3.99, 95% CI: 0.92–17.35). Regression analyses also showed the risk of an SPC-HE was greater in alcohol drinkers than those who did not (aRR: 1.65, 95% CI: 1.10–2.48). Conclusions: Compared with the initial cancer in the lip, patients with a cancer in the oropharynx, floor of mouth, and hard palate had a higher risk for the SPC-HE. ? 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved[SDGs]SDG3alcohol; helium; adult; Article; cancer incidence; cancer risk; cancer screening; cigarette smoking; comparative study; controlled study; drinking behavior; esophagus cancer; female; hard palate; high risk patient; human; hypopharynx cancer; lip cancer; major clinical study; male; mass screening; mastication; mouth cancer; oropharynx cancer; pharynx cancer; primary tumor; priority journal; regression analysis; risk assessment; risk factor; second cancer; survival analysis; Taiwan; tongue cancer; aged; esophagus tumor; hypopharynx; hypopharynx tumor; middle aged; mouth tumor; pathology; second cancer; squamous cell carcinoma; very elderly; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Esophageal Neoplasms; Female; Humans; Hypopharyngeal Neoplasms; Hypopharynx; Male; Middle Aged; Mouth Neoplasms; Neoplasms, Second Primary; Taiwanjournal article10.1111/odi.13080308218832-s2.0-85063519898