Wong J.Y.Y.Zhang HHsiung C.A.Shiraishi K.Yu K.Matsuo K.Wong M.P.Hong Y.-C.Wang J.Seow W.J.Wang Z.Pang H.Li Y.Choi J.E.Park K.H.Sung S.W.Liu L.Kang C.H.Zhu M.Chen C.-H.Yang T.-Y.Song M.Xu J.Guan P.Tan W.Wang C.-L.Hsin M.Sit K.-Y.Ho J.Chen Y.Choi Y.Y.Hung J.-Y.Kim H.N.Kim J.S.Yoon H.I.Lin C.-C.Park I.K.Xu P.Wang Y.He Q.Perng R.-P.Chen C.-Y.Vermeulen R.Chang I.-S.Wu J.Lim W.-Y.Chen K.-C.Li Y.-J.Li J.Chen H.CHONG-JEN YUJin L.Chen T.-Y.Jiang S.-S.Chatterjee N.Liu J.Yamaji T.Hicks B.Wyatt K.Li S.A.Dai J.Ma H.Jin G.Song B.Wang Z.Hu W.Cheng S.Li X.Ren Y.Cui P.Iwasaki M.Shimazu T.Tsugane S.Zhu J.Yang K.Jiang G.Wu C.Fei K.Wu G.Lin H.-C.Chen H.-L.Fang Y.-H.Tsai F.-Y.Hsieh W.-S.Yu J.Stevens V.L.Laird-Offringa I.A.Mitsudomi T.Marconett C.N.Rieswijk L.Chao A.PAN-CHYR YANGShu X.-O.Wu T.Wu Y.L.Lin D.Chen K.Zhou B.Zheng W.Huang Y.-C.Kohno T.Shen H.Chanock S.J.Rothman N.Lan Q.Kim J.H.Seow A.Caporaso N.E.Shin M.-H.Chung L.P.An S.-J.Wang P.Yang Y.Zheng H.Yatabe Y.Zhang X.-C.Kim Y.T.Cai Q.Yin Z.Kim Y.-C.Bassig B.A.Chang J.Ho J.C.M.Ji B.-T.Daigo Y.Ito H.Momozawa Y.Ashikawa K.Kamatani Y.Honda T.Hosgood H.D.Sakamoto H.Kunitoh H.Tsuta K.Watanabe S.-I.Kubo M.Miyagi Y.Nakayama H.Matsumoto S.Tsuboi M.Goto K.Shi J.Song L.Hua X.Takahashi A.Goto A.Minamiya Y.Shimizu K.Tanaka K.Wei F.Matsuda F.Su J.Kim Y.H.Oh I.-J.Song F.Su W.-C.Chen Y.-M.Chang G.-C.KUAN-YU CHENHuang M.-S.Chien L.-H.Xiang Y.-B.Park J.Y.Kweon S.-S.Chen C.-J.Lee K.-M.Blechter B.Li H.Gao Y.-T.Qian B.Lu D.Liu J.Jeon H.-S.Hsiao C.-F.Sung J.S.Tsai Y.-H.Jung Y.J.Guo H.Hu Z.Wang W.-C.Chung C.C.Burdett L.Yeager M.Hutchinson A.Berndt S.I.Wu W.2020-12-022020-12-0220200888-7543https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068966697&doi=10.1016%2fj.ygeno.2019.07.008&partnerID=40&md5=2f03da81363ca97dba6e57d733f19b1bhttps://scholars.lib.ntu.edu.tw/handle/123456789/523428We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysis with the adaptive rank truncated product method was used to assess the association between a TB-related gene-set and lung adenocarcinoma using GWAS data from 5512 lung adenocarcinoma cases and 6277 controls. The gene-set consisted of 31 genes containing known/suggestive associations with genetic variants from previous TB-GWAS. Subsequently, we followed-up with Mendelian Randomization to evaluate the association between TB and lung adenocarcinoma using three genome-wide significant variants from previous TB-GWAS in East Asians. The TB-related gene-set was associated with lung adenocarcinoma (p = 0.016). Additionally, the Mendelian Randomization showed an association between TB and lung adenocarcinoma (OR = 1.31, 95% CI: 1.03, 1.66, p = 0.027). Our findings support TB as a causal risk factor for lung cancer development among never-smoking Asian women. ? 2019[SDGs]SDG3HLA DQA1 antigen; adult; Article; controlled study; DLG2 gene; East Asian; female; FHAD1 gene; gene; genetic association; genetic susceptibility; genetic variability; genome-wide association study; HLA DQA1 gene; human; LRRC69 gene; lung adenocarcinoma; major clinical study; MEIS2 gene; Mendelian randomization analysis; never smoker; observational study; pathway analysis; priority journal; single nucleotide polymorphism; statistical analysis; tuberculosis; ZFPM2 gene; Asian continental ancestry group; genetics; lung adenocarcinoma; lung tuberculosis; lung tumor; Adenocarcinoma of Lung; Asian Continental Ancestry Group; Female; Genome-Wide Association Study; Humans; Lung Neoplasms; Mendelian Randomization Analysis; Non-Smokers; Tuberculosis, Pulmonaryjournal article10.1016/j.ygeno.2019.07.008313067482-s2.0-85068966697