Liang J.-S.WANG-TSO LEEYoung C.STEVEN SHINN-FORNG PENGShen Y.-Z.2020-09-222020-09-2220020887-8994https://scholars.lib.ntu.edu.tw/handle/123456789/514187Agyria-pachygyria complex is a disorder of neuronal migration and organization. Patients suffer either motor or intellectual retardation. We report our experiences of 10 patients with agyria-pachygyria complex and evaluate their clinical features, electroencephalography, and evoked potentials. Of nine electroencephalography examinations, five patients demonstrated characteristically high-amplitude fast activity. One of nine patients had an abnormal brainstem auditory-evoked potential. Three of seven patients had abnormal goggled visual-evoked potential. Six patients received somatosensory-evoked potential examinations, and five of these were abnormal, including four with prolonged central conduction times. Of the 10 patients, eight survived with variable intellectual and motor retardation; two died of sepsis. Patients with grades 1-4 agyria-pachygyria had high incidences of somatosensory-evoked potential abnormalities and also suffered worse neurologic outcomes. Normal brainstem auditory-evoked potential but abnormal cortical somatosensory-evoked potential components and prolonged central conduction time in these patients indicate that agyria-pachygyria is a supratentorial disease. We conclude that somatosensory-evoked potential examination is supplemental to neuroimaging in predicting the neurologic prognosis of patients with agyria-pachygyria. ? 2002 by Elsevier Science Inc. All rights reserved.[SDGs]SDG3adolescent; agyria; article; brain region; child; clinical article; clinical feature; controlled study; correlation analysis; disease severity; electroencephalography; evoked brain stem auditory response; evoked cortical response; evoked response; evoked somatosensory response; evoked visual response; female; human; imaging; intellectual impairment; male; motor retardation; nerve conduction; neurologic disease; neurophysiology; pachygyria; prediction; priority journal; prognosis; sepsis; survival; Adolescent; Brain; Child; Child, Preschool; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Humans; Infant; Magnetic Resonance Imaging; Male; Mental Retardation; Neural Conduction; Neurologic Examination; Neurons; Prognosis; Psychomotor Disorders; Reaction Time; Spasms, Infantilejournal article10.1016/S0887-8994(02)00401-0123931262-s2.0-0036710998