Lu C.-HYeh Y.-C.YI-CHEUN YEH2022-03-222022-03-22202116136810https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119158401&doi=10.1002%2fsmll.202105997&partnerID=40&md5=089bf7bcfad4d3bfedb489061711e24ehttps://scholars.lib.ntu.edu.tw/handle/123456789/601367Nanocomposite double-network hydrogels (ncDN hydrogels) have been demonstrated as promising biomaterials to present several desired properties (e.g., high mechanical strength, stimuli-responsiveness, and local therapy) for biomedicine. Here, a new type of ncDN hydrogels featuring definable microstructures and properties as well as multistimuli responsiveness for controlled release applications is developed. Amine-functionalized iron oxide nanoparticles (IOPs_NH2) are used as nanoparticle cross-linkers to simultaneously connect the dual networks of gelatin (Gel) and polydextran aldehyde (PDA) through hydrogen bonding, electrostatic interactions, and dynamic imine bonds. The pH- and temperature-responsive Gel/PDA/IOP_NH2 ncDN hydrogels present a fast release profile of proteins at acidic pH and high temperature. Besides, IOP_NH2 also contributes the magnetic-responsiveness to the ncDN hydrogels, allowing the use of magnetic field to generate heat to facilitate the structural change of hydrogels and the subsequent applications. Taken together, a versatile ncDN hydrogel platform capable of multistimuli responsiveness and local heating for controlled release is developed for advanced biomedical applications. ? 2021 Wiley-VCH GmbHHydrogelsHydrogen bondsIron oxidesMedical applicationsNanomagneticsNanoparticlesControlled releaseDouble networkDouble-network hydrogelsDynamic covalent bondHigh mechanical strengthMagnetic nanocompositesMulti-responsiveNanocomposite hydrogelsPropertyStimuli responsivenessNanocompositesbiomaterialnanocompositedelayed release formulationhydrogelmagnetismBiocompatible MaterialsDelayed-Action PreparationsMagnetic Phenomenajournal article10.1002/smll.202105997347917962-s2.0-85119158401