Tseng C.-D.FU-TIEN CHIANGHsu K.-L.Lo H.-M.Tseng Y.-Z.2021-03-112021-03-1119981011-6842https://scholars.lib.ntu.edu.tw/handle/123456789/551819Background. The anti-hypertensive effect of slow released nifedipine [Nifelan?20mg] in Chinese patient has not been reported. This study is attempt to investigate the clinical efficacy and safety of Nifelan in Chinese patients with mild to moderate hypertension. Materials and methods. A total of 40 patients who were on this once-daily regimen were observed and compared with the effect of an intermediate form of nifedipine [Adalat Retard 20mg]. Before and after treatment with either Nifelan or Adalat Retard, sitting blood pressure (BP), heart rate (HR), blood cell count, urinalysis, biochemical profile, ECG and ambulatory blood pressure monitoring (ABPM, in 20 patients only) were examined. Side effects were also recorded at each visit. Results and conclusion. We found that Nifelan and Adalat Retard could significantly reduce the causal BP and ambulatory BP averages during the whole day, the daytime and the nighttime periods. Both drugs increased the causal heart rate but not the ambulatory heart rate. These effects were similar between Nifelan and Adalat Retard treatment. About 12.5 to 15% developed mild and transient side effects including headache, flushing of face, constipation, numbness of digits and leg edema during taking either drug. Based on these observations, we conclude that Nifelan once daily is an effective and safe regimen for the treatment of Chinese patients with mild to moderate hypertension.Ambulatory blood pressure monitoring; Casual BP; Hypertension; Nifelan[SDGs]SDG3nifedipine; adult; aged; antihypertensive activity; antihypertensive therapy; article; blood pressure regulation; clinical article; constipation; disease severity; drug efficacy; electrocardiogram; female; flushing; headache; human; hypertension; leg edema; malejournal article2-s2.0-0031817117