Chang C.-C.YUNG-MING JENGPeng M.Keppeke G.D.Sung L.-Y.LI-YING SUNG2020-03-062020-03-0620170014-4827https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032961802&doi=10.1016%2fj.yexcr.2017.10.030&partnerID=40&md5=a04c2d39aa428f97018702675792e4echttps://scholars.lib.ntu.edu.tw/handle/123456789/473277CTP synthase (CTPS) can aggregate into an intracellular macrostructure, the cytoophidium, in various organisms including human cells. Previous studies have shown that assembly of human CTPS cytoophidia may be correlated with the cellular metabolic status, and is able to promote the activity of CTPS. A correlation between the cytoophidium and cancer metabolism has been proposed but not yet been revealed. In the current study we provide clear evidence of the presence of CTPS cytoophidia in various human cancers and some non-cancerous tissues. Moreover, among 203 tissue samples of hepatocellular carcinoma, 56 (28%) samples exhibited many cytoophidia, whereas no cytoophidia were detected in adjacent non-cancerous hepatocytes for all samples. Our findings suggest that the CTPS cytoophidium may participate in the adaptive metabolism of human hepatocellular carcinoma. ? 2017[SDGs]SDG3cytidine triphosphate synthase; cytidine triphosphate synthase; heat shock protein 90; ligase; protein aggregate; tumor protein; adult; aged; Article; controlled study; cytoophidium; cytoplasm; female; Huh-7 cell line; human; human cell; human tissue; liver cell; liver cell carcinoma; liver tissue; major clinical study; male; priority journal; protein expression; quantitative analysis; tissue microarray; chemistry; gene expression; genetics; liver cell carcinoma; liver tumor; metabolism; middle aged; mortality; pathology; tumor cell line; Aged; Carbon-Nitrogen Ligases; Carcinoma, Hepatocellular; Cell Line, Tumor; Female; Gene Expression; Hepatocytes; HSP90 Heat-Shock Proteins; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Proteins; Protein Aggregatesjournal article10.1016/j.yexcr.2017.10.030290971812-s2.0-85032961802