HAO-CHUN CHANGCHIA-LIN HSUYIH-LEONG CHANGCHONG-JEN YU2020-12-242020-12-2420202051-3380https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087857250&doi=10.1002%2frcr2.597&partnerID=40&md5=5f829c22eb010ae0658ee86e0dd125e7https://scholars.lib.ntu.edu.tw/handle/123456789/531102Adenocarcinoma (ADC) is the most common form of lung cancer; however, some other types of lung cancer can sometimes mimic ADC. It then takes experienced pathologists and special stains to make the correct diagnosis. Here, we present a patient with pulmonary pleomorphic carcinoma who was misdiagnosed with ADC, and was treated with pembrolizumab for 13 months. The diagnosis and treatment (including immunotherapy) are also reviewed. ? 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology[SDGs]SDG3carboplatin; cytokeratin; epidermal growth factor receptor; homeobox protein Nkx 2.1; pembrolizumab; pemetrexed; piperacillin plus tazobactam; programmed death 1 ligand 1; vimentin; abdominal hysterectomy; adult; anuria; Article; blood transfusion; bone metastasis; brain metastasis; case report; cause of death; clinical article; coughing; diagnostic error; disseminated intravascular clotting; dyspnea; dysuria; endobronchial ultrasonography; fasciotomy; female; fever; gene mutation; hematuria; human; human tissue; hyperkalemia; lactic acidosis; leukocytosis; limb weakness; lung adenocarcinoma; lung biopsy; lung carcinoma; malaise; menstruation; middle aged; multiple cycle treatment; multiple organ failure; muscle hematoma; muscle necrosis; myomectomy; nuclear magnetic resonance imaging; pain; pleura effusion; positron emission tomography; protein expression; pulmonary pleomorphic carcinoma; pyuria; salpingooophorectomy; shock; sputum; stereotactic radiosurgery; thorax radiography; transbronchial aspiration; transvaginal echography; tumor bleeding; uterus myoma; video assisted thoracoscopic surgery; whole body scintiscanningjournal article10.1002/rcr2.5972-s2.0-85087857250