Chen, PJPJChenChiu, CHCHChiuTseng, JKJKTsengYang, KTKTYangYI-CHEN CHENCHIH-HSIEN CHIU2019-09-262019-09-2620151756-4646https://scholars.lib.ntu.edu.tw/handle/123456789/425194© 2015 Elsevier Ltd. D-Glucuronolactone (C<inf>6</inf>H<inf>8</inf>O<inf>6</inf>, lactone), naturally found in plant gums, is commercially acclaimed for its hepatoprotective effects. This study was to investigate whether lactone can attenuate thioacetamide (TAA)-induced liver fibrosis in a rat model. Results showed that lactone supplementation (75mgkg^-1 bw glucuronolactone) alleviated AST values in TAA-intraperitoneally-injected rats (100mgkg^-1 bw TAA) and increased antioxidant capacity of liver via elevations of antioxidant enzymes activities [superoxide dismutase (SOD) and glutathione peroxidase (GPx)], glutathione (GSH) and trolox equivalent antioxidative capacity (TEAC) levels (p<0.05). Down-regulated (p<0.05) expression of inflammation including interleukin-6 (IL-6), nuclear factor-kappa B (NF-κB), activator protein 1 (AP-1), krüppel-like factor 6 (KLF-6), and fibrosis related fibrotic factors, i.e., alpha smooth muscle actin (α-SMA), and collagen alpha1 (I) (COLα1) through lactone supplementation underlay the lower collagen contents and less severe liver damage on histopathology observations. Therefore, hepatoprotection of lactone against TAA-induced liver fibrosis can be attributed to the amelioration of oxidative stress and inflammation.Anti-inflammation; Antioxidant; D-glucuronolactone; Liver fibrosis; Thioacetamide10.1016/j.jff.2015.01.0262-s2.0-84926393740WOS:000364500000016https://api.elsevier.com/content/abstract/scopus_id/84926393740