Chassillan LYamashita YWoo-Jin YooToffano MGuillot RKobayashi SVo-Thanh G.2022-04-252022-04-25202114770520https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121625449&doi=10.1039%2fd1ob01953h&partnerID=40&md5=658e394654d30bb4b5be505a872f4ddahttps://scholars.lib.ntu.edu.tw/handle/123456789/606947The enantioselective hydrophosphonylation ofN-Boc imines was investigated using a new family of pseudo-symmetric guanidine-thiourea catalysts, providing α-amino phosphonates in moderate to high yields with good enantioselectivity. The catalyst was heterogenized by polymerization with styrene and the resulting catalyst was applied to reactions under continuous-flow conditions. ? The Royal Society of Chemistry 2021.CatalystsStyreneThioureasAminophosphonatesContinuous-flowEnantioselectiveFlow conditionHigher yieldHydrophosphonylationReaction underSymmetricsThiourea catalysts]+ catalystEnantioselectivityEnantioselective hydrophosphonylation ofN-Boc imines using chiral guanidine-thiourea catalystsjournal article10.1039/d1ob01953h348706702-s2.0-85121625449