Tai H.-C.TONG-YUAN TAIWEI-SHIUNG YANGWang S.-W.HONG-JENG YU2021-02-022021-02-0220161056-8727https://www.scopus.com/inward/record.uri?eid=2-s2.0-84961924594&doi=10.1016%2fj.jdiacomp.2016.01.002&partnerID=40&md5=a96c79209f7ed8e4dba61588bec5e31ahttps://scholars.lib.ntu.edu.tw/handle/123456789/544116Aims Patients with diabetes are predisposed to develop a variety of complications, including lower urinary tract (LUT) dysfunction. We aimed to examine the associations between glycemic control and LUT dysfunction in women with type 2 diabetes (T2D). Methods We included 400 women with T2D (age range, 48-75 years) in this cross-sectional analysis. The participants were divided into tertiles according to glycosylated hemoglobin (HbA1c) measurements. The mean HbA1c levels for tertiles 1, 2, and 3 were 6.2% (N = 132), 7.1% (N = 132), and 8.4% (N = 136), respectively. We evaluated LUT dysfunction with the American Urological Association Symptom Index (AUA-SI) questionnaire, uroflowmetry (UFM), and post-void residual (PVR). Results No significant differences were found among HbA1c tertiles regarding storage, voiding and total AUA-SI scores, and prevalence of LUT symptoms. However, women in tertile 3 had higher prevalences of severe LUT symptoms (AUA-SI ? 20) and clinically significant PVR (? 100 mL) compared to women in the other tertiles. Multivariate analysis revealed that diabetic neuropathy, but not HbA1c, significantly predicted LUT symptoms in women with T2D after adjustment for age, body mass index (BMI) and hypertension. However, HbA1c was associated with an increased risk of developing clinically significant PVR. Conclusions Our findings do not support significant associations between glycemic control and LUT symptoms in women with T2D. However, women with poor glycemic control are more likely to develop urinary retention than women with proper glycemic control. Clinicians should, therefore, be aware of and educate patients about the association between urinary retention and glycemic control. ? 2016 Elsevier Inc.[SDGs]SDG3hemoglobin A1c; insulin; oral antidiabetic agent; glucose blood level; glycosylated hemoglobin; hemoglobin A1c protein, human; adult; aged; American Urological Association Symptom Index; Article; body mass; cross-sectional study; diabetic nephropathy; diabetic neuropathy; diabetic retinopathy; disease association; female; glycemic control; human; hypertension; lower urinary tract symptom; major clinical study; non insulin dependent diabetes mellitus; postvoid residual urine volume; prevalence; priority journal; risk factor; urine retention; blood; complication; Diabetes Mellitus, Type 2; glucose blood level; Lower Urinary Tract Symptoms; metabolism; middle aged; pathophysiology; urinary tract; Aged; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Hemoglobin A, Glycosylated; Humans; Lower Urinary Tract Symptoms; Middle Aged; Urinary Tractjournal article10.1016/j.jdiacomp.2016.01.002268619462-s2.0-84961924594