Adrenalectomy Completely Cured Hypertension in Patients with Familial Hyperaldosteronism Type I Who Had Somatic KCNJ5 Mutation

Lin, Yu-FangYu-FangLinPeng, Kang-YungKang-YungPengChang, Chia-HuiChia-HuiChangHu, Ya-HuiYa-HuiHuVIN-CENT WUSHIH-CHIEH CHUEHKWAN-DUN WU2019-09-192019-09-192019-07-090021-972X1945-7197https://scholars.lib.ntu.edu.tw/handle/123456789/424770Familial hyperaldosteronism type I or glucocorticoid-remediable aldosteronism (FH-I; GRA) is caused by unequal crossing-over of the steroid 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) genes. Somatic KCNJ5 mutations have not been reported in patients with GRA; therefore, the appropriate treatment and prognosis of such concurrent cases remain unknown.enAdrenalectomy Completely Cured Hypertension in Patients with Familial Hyperaldosteronism Type I Who Had Somatic KCNJ5 Mutationjournal article10.1210/jc.2019-0068931287546