謝國煌2006-07-262018-06-292006-07-262018-06-292005-07-31http://ntur.lib.ntu.edu.tw//handle/246246/16308本研究計畫合成奈米親/疏水鏈段不同成 分的聚胺酯生醫材料,利用其表面出現奈米親 /疏水區相間的結構以達到抗血栓的目的。第 一部份我們在親水鏈段方面可使用生物相容 性良好的聚麩胺酸(poly-γ-glutamic acid)、PEG 和PBA 等材料, 疏水鏈段方面我們用 silicone、含氟的化合物和PTMO 來和上面的 親水鏈段合成以形成奈米結構的親/疏水生醫 材料來減低血栓形成的機率。第二部份我們在 聚胺酯上鋪上一層heparin 或是引進磺酸鹽、 羧酸等官能基在聚胺酯的結構上以增進其生 物相容性和降低血栓之形成。第三部份我們利 用之前研發台大一號人工心臟的材料技術轉 移到人工血管使其內部因為奈米親/疏水結構 延緩血栓的產生以達到抗凝血的目的,其外部 也因為這個結構使細胞難以附著在上面以達 到抗發炎的目的。人工敷料方面,我們因為其 結構使壞的細胞難以附著上去以達到抗發炎 還可以因為我們的敷料形成的一層保護膜阻 隔外在的髒東西侵入我們的傷口引發感染,也 可以利用我們所引進的磺酸鹽和羧酸等陰離 子的官能基來達到殺菌的功能。In the study, a series of novel polyurethane materials with nano hydrophilic/hydrophobic segments on the materials’ surface are prepared and for application of anticoagulant. First , using hydrophilic segment materials (like poly-γ-glutamic acid, PEG and PBA) and hydrophobic segment materials (like PTMS, PTMO and compounds with F) to prepare the nano hydrophilic/hydrophobic domains of polyurethane materials. Second, preparing polyurethane coating heparin and using chain extender with sulfonated groups and carboxylic groups to resist thrombin. Finally, we used our ventricular assist device skill transport to our blood vessel with nano segmental hydrophilic/hydrophobic structure resisting thrombin and resisting fester outside the blood vessel. In wound dressing, our structure could adhere bad cell difficultly and resist fester. Using sulfonated and carboxylic groups, our wound dressing could antifungal and block dirt into the rip.application/pdf183572 bytesapplication/pdfzh-TW國立臺灣大學高分子科學與工程學研究所奈米親/疏水鏈段聚胺酯生醫材料之研究reporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/16308/1/932216E002011.pdf