Huang, Yih HwenYih HwenHuangYEN-HUNG LINRUOH-FANG YENHou, Charles Jia YinCharles Jia YinHouWang, Shan YingShan YingWangTsai, Shih ChuanShih ChuanTsaiHo, Kung ChuKung ChuHoLin, Ming HsienMing HsienLinTsao, Chin HoChin HoTsaoChang, Chih YungChih YungChangHuang, Jin LongJin LongHuangMEI-FANG CHENGYEN-WEN WU2021-11-192021-11-192021-01-0110116842https://scholars.lib.ntu.edu.tw/handle/123456789/587247Transthyretin cardiac amyloidosis (ATTR-CM) is an increasingly recognized cause of heart failure with preserved ejection fraction. Favorable prognosis depends on early diagnosis and correct treatment strategy. Among patients for whom there is a high clinical suspicion of cardiac amyloidosis,99mTc-labeled bone avid scintigraphy including99mTc-pyrophosphate (PYP) scintigraphy may be of diagnostic and prognostic importance. Various international guidelines support the non-biopsy diagnosis of ATTR-CM using99mTc-PYP scintigraphy, yet emphasize the gap in standardization of acquisition and imaging analysis protocols, as well as the appropriateness of its clinical use. Therefore, a joint expert consensus has been reached by the Taiwan Society of Cardiology and the Society of Nuclear Medicine of the Republic of China, to advocate for the application of99mTc-PYP scintigraphy in the diagnosis of ATTR-CM. This article aims to highlight the recommendations on image acquisition, qualitative and quantitative assessments of cardiac99mTc-PYP uptake, and diagnostic algorithms. We hope the implementation of these recommendations in Taiwan will facilitate the process and enhance the diagnostic rate of ATTR-CM.99m Tc-pyrophosphate (PYP) | Cardiac amyloidosis | Cardiomyopathy | Heart failure | Scintigraphy | Transthyretin[SDGs]SDG3brain natriuretic peptide; cadmium; creatinine; gadolinium; pyrophosphate; pyrophosphate technetium tc 99m; quinine; technetium 99m; transthyretin; abdominal injury; accuracy; adult; AL amyloidosis; algorithm; amyloid neuropathy; angiocardiography; arteryjournal article10.6515/ACS.202105_37(3).20210420A2-s2.0-85105740104