YAO-HSU YANGHSIN-HUI YUBOR-LUEN CHIANG2020-12-172020-12-1720141568-9972https://www.scopus.com/inward/record.uri?eid=2-s2.0-84896318066&doi=10.1016%2fj.autrev.2014.01.031&partnerID=40&md5=a484fff3f7d6debb75e49c6ee8738946https://scholars.lib.ntu.edu.tw/handle/123456789/527049Henoch-Sch?nlein purpura (HSP) is a common childhood systemic vasculitis with clinical characteristics of cutaneous palpable purpura, arthralgia/arthritis, bowel angina, and hematuria/proteinuria. HSP is identified mainly based on the above presentations. Combined with pathohistological findings of leukocytoclastic vasculitis (LCV) and IgA-immune deposits in vessel walls and/or glomeruli increase the diagnostic sensitivity and specificity. However, considering the accessibility of biopsy and some patients with atypical presentations, there are still medical unmet needs in HSP diagnosis. This article reviews the diagnosis of HSP including the aspects of classification criteria, differential diagnosis, and some laboratory findings as the biomarkers with diagnostic potential. ? 2014 Elsevier B.V.[SDGs]SDG3antinuclear antibody; autoantibody; biological marker; immunoglobulin A; immunoglobulin heavy chain; phospholipid antibody; acute abdomen; anaphylactoid purpura; ANCA associated vasculitis; arthralgia; arthritis; blood vessel wall; cryoglobulinemia; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; differential diagnosis; disease classification; disseminated intravascular clotting; fever; gastrointestinal hemorrhage; glomerulus; glycosylation; granulocyte; hematuria; histopathology; human; immune complex deposition; immunoglobulin A nephropathy; immunoglobulin deposition; juvenile dermatomyositis; kidney biopsy; laboratory test; leukocytoclastic vasculitis; leukocytosis; membranoproliferative glomerulonephritis; microscopic polyangiitis; mixed connective tissue disease; onset age; polyarteritis; purpura; review; rheumatoid arthritis; sensitivity and specificity; septicemia; Sjoegren syndrome; skin biopsy; small vessel vasculitis; systemic lupus erythematosus; systemic vasculitis; thrombocytopenic purpura; upper respiratory tract infection; vasculitis; Biomarker; Diagnostic criteria; Differential diagnosis; Henoch-Sch?nlein purpura; Arthritis; Biological Markers; Congresses as Topic; Consensus Development Conferences as Topic; Diagnosis, Differential; Humans; Purpura, Schoenlein-Henochreview10.1016/j.autrev.2014.01.031244241882-s2.0-84896318066