Glucose Conferred Irinotecan Chemoresistance through Divergent Actions of Pyruvate and ATP in Cell Death and Proliferation of Colorectal Cancer

Huang, Chung-YenChung-YenHuangPai, Yu-ChenYu-ChenPaiLINDA CHIA-HUI YU2023-01-172023-01-1720220030-2414https://scholars.lib.ntu.edu.tw/handle/123456789/627337Altered glucose metabolism is associated with chemoresistance in colorectal cancer (CRC). This study aimed to illustrate the molecular mechanisms of glucose-mediated chemoresistance against irinotecan, a topoisomerase I inhibitor, focusing on the distinct roles of metabolites such as pyruvate and ATP in modulating cell death and proliferation.enCell cycle progression; Chemoresistance; Glucose metabolism; Programmed cell death; Spheroid cultures; Xenograft tumors[SDGs]SDG3Glucose Conferred Irinotecan Chemoresistance through Divergent Actions of Pyruvate and ATP in Cell Death and Proliferation of Colorectal Cancerjournal article10.1159/000525977358501022-s2.0-85139571823WOS:000864744500005https://api.elsevier.com/content/abstract/scopus_id/85139571823