Chang, Wei-ChiehWei-ChiehChangChang, Cheng-ChangCheng-ChangChangChung, Ren-JeiRen-JeiChungWEI-BOR TSAI2026-01-152026-01-152026-0101418130https://www.scopus.com/record/display.uri?eid=2-s2.0-105024710263&origin=resultslisthttps://scholars.lib.ntu.edu.tw/handle/123456789/735358Postoperative adhesion formation remains a critical challenge in abdominal and pelvic surgeries involving mesh implantation. In this study, we developed an anti-adhesion hydrogel by photo-crosslinking methacrylated carboxymethyl cellulose (CMCMA) with maleated collagen (ColME), which was infused into surgical meshes for anti-adhesion. The CMCMA/ColME hydrogel exhibited shear-thinning behavior, high water content, and tunable mechanical properties, as well as good cytocompatibility. In a rat cecal abrasion model, the hydrogel reduced intra-abdominal adhesion scores to 0 compared to untreated group 3 ± 2.07 (p < 0.05). When applied to surgical polypropylene mesh in a rat pelvic implantation model, the hydrogel-infused mesh demonstrated significantly lower adhesion scores (mean score 0.17 ± 0.41 vs. 4 ± 0.76, p < 0.001) and minimal tissue inflammatory. Histological and immunohistochemical analyses revealed diminished collagen deposition and macrophage infiltration around the hydrogel-infused mesh. These findings indicate that the CMCMA/ColME hydrogel provides an effective barrier to prevent postoperative adhesions, with high biocompatibility and potential clinical applicability in abdominal and pelvic repair procedures.falseAnti-adhesion hydrogel-infused meshCarboxymethyl cellulose (CMC)Type I collagen (Col)journal article10.1016/j.ijbiomac.2025.1494132-s2.0-105024710263