Wang W.-K.Chen M.-Y.Chuang C.-Y.Jeang K.-T.LI-MIN HUANG2021-06-242021-06-2420000253-2662https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033774735&partnerID=40&md5=010432a2bfa1e9329f1b73d989bcfe7ehttps://scholars.lib.ntu.edu.tw/handle/123456789/566680Since the discovery of human immunodeficiency virus (HIV) as the etiologic agent of acquired immune deficiency syndrome (AIDS) more than a decade ago, tremendous progress has been made in various aspects of this virus and its interplay with the host immune system. The advent of potent combination therapy has made it possible to achieve effective and durable control of HIV-1 replication in vivo, yet the persistence of the latent reservoirs pose a new challenge. The recent identifications of several cellular proteins interacting with different viral gene products have not only shed new insights into our understanding of the HIV-1 and the host cell biology, but also provided the bases for developing novel strategies to block HIV-1 replication. It is from this perspective that we review the current understanding of the molecular mechanisms governing the HIV-1 life cycle.Human immunodeficiency virus type 1 (HIV-1); Molecular biology[SDGs]SDG3[SDGs]SDG12antiretrovirus agent; cell protein; gene product; acquired immune deficiency syndrome; combination chemotherapy; Human immunodeficiency virus 1; immune response; molecular biology; persistent virus infection; review; virus cell interaction; virus gene; virus replication; Base Sequence; Gene Expression Regulation, Viral; Genes, rev; Genes, tat; HIV-1; Molecular Sequence Data; Transcription, Genetic; Virion; Virus Assembly; Virus Latency; Virus Replicationreview110453742-s2.0-0033774735