Cisplatin and Albumin-Based Gold-Cisplatin Nanoparticles Enhance Ablative Radiation Therapy-Induced Antitumor Immunity in Local and Distant Tumor Microenvironment

JENNY LING-YU CHENYang, Shu-JyuanShu-JyuanYangPan, Chun-KaiChun-KaiPanLin, Li-ChengLi-ChengLinTsai, Ching-YiChing-YiTsaiWang, Chung-HaoChung-HaoWangYU-SEN HUANGLin, Yu-LiYu-LiLinSUNG-HSIN KUOMING-JIUM SHIEH2023-05-052023-05-052023-02-1303603016https://scholars.lib.ntu.edu.tw/handle/123456789/630870Ablative radiation therapy (RT) is an important strategy to eliminate primary tumor and can potentially induce the abscopal effect. Human serum albumin nanoparticle (NP) was used for controlled release of cisplatin to decrease cisplatin's systemic toxicity, and gold (Au) was added to increase RT-induced immunogenic cell death and potentiate the abscopal antitumor immunity.en[SDGs]SDG3Cisplatin and Albumin-Based Gold-Cisplatin Nanoparticles Enhance Ablative Radiation Therapy-Induced Antitumor Immunity in Local and Distant Tumor Microenvironmentjournal article10.1016/j.ijrobp.2023.02.014367920142-s2.0-85150045555https://api.elsevier.com/content/abstract/scopus_id/85150045555