Tan E.KLu C.SPeng RTeo Y.YWu-Chou Y.HChen R.SWeng Y.HChen C.MFung H.CTan L.CZhang Z.JAn X.KLee-Chen G.JLee M.CFook-Chong SBurgunder J.MRUEY-MEEI WUWu Y.R.2020-02-252020-02-2520100197-4580https://scholars.lib.ntu.edu.tw/handle/123456789/463693The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD. ? 2008 Elsevier Inc.[SDGs]SDG3ubiquitin carboxy terminal hydrolase L1; ubiquitin thiolesterase; unclassified drug; adolescent; adult; aged; article; Caucasian; Chinese; controlled study; dimerization; ethnicity; gene frequency; genetic analysis; genetic association; genetic linkage; genetic polymorphism; genetic variability; human; logistic regression analysis; major clinical study; Parkinson disease; priority journal; protein protein interaction; Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Asian Continental Ancestry Group; Female; Genetic Association Studies; Genetic Variation; Humans; Male; Middle Aged; Parkinson Disease; Singapore; Taiwan; Ubiquitin Thiolesterase; Ubiquitination; Young Adultjournal article10.1016/j.neurobiolaging.2008.11.008193292252-s2.0-78650174666