內科CHANG, TIEN-CHUNTIEN-CHUNCHANG2008-12-292018-07-112008-12-292018-07-112001http://ntur.lib.ntu.edu.tw//handle/246246/95157Purpose : To evaluate prolonged low dose-rate gamma - exposure effects on the thyroid glands of residents living in Co-60-contaminated steel buildings. Materials and methods : Physical examination and ultrasonography of the thyroid, determination of thyroid function and anti -thyroid microsomal antibodies were performed for 1346 residents. Ultrasound-guided aspiration cytology was done for thyroid nodules. The study subjects were stratified by age at examination (less than or equal to 15 and >15 years), sex and exposure dose to the body. Dose-response data on the prevalence of various thyroid diseases were analysed by the multiple logistic regression analysis. Results and conclusions : The prevalence of simple goitre was related to the exposure with a dose- response relationship for males of all ages, and for females of less than or equal to 15 years . There was a biological gradient of thyroid cyst prevalence with the increase in exposure dose for females of all ages. The prevalence of elevated serum tri-iodothyronine level showed a dose- response relationship for males of less than or equal to 15 years. A significant increase in thyroid abnormalities with dose was observed for males of all ages, and for females of less than or equal to 15 years.en-USCONTAMINATED REBARCHERNOBYL DISASTERCHILDRENADOLESCENTSABNORMALITIESPREVALENCEjournal article