Wu, Chia-HsinChia-HsinWuHsieh, Chia-ShanChia-ShanHsiehChang, Yo-ChengYo-ChengChangHuang, Chi-ChengChi-ChengHuangYeh, Hsien-TanHsien-TanYehHou, Ming-FengMing-FengHouChung, Yuan-ChiangYuan-ChiangChungTu, Shih-HsinShih-HsinTuKING-JEN CHANGAmrita ChattopadhyayLiang-Chuan LaiTZU-PIN LULi, Yung-HuaYung-HuaLiMONG-HSUN TSAIERIC YAO-YU CHUANG2022-02-152022-02-15202123993642https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114685446&doi=10.1038%2fs42003-021-02597-x&partnerID=40&md5=0e851f0ba115246a64f726a666b98adbhttps://scholars.lib.ntu.edu.tw/handle/123456789/594620Whole-genome doubling (WGD) is an early macro-evolutionary event in tumorigenesis, involving the doubling of an entire chromosome complement. However, its impact on breast cancer subtypes remains unclear. Here, we performed a comprehensive and quantitative analysis of WGD and its influence on breast cancer subtypes in patients from Taiwan and consequently highlight the genomic association between WGD and homologous recombination deficiency (HRD). A higher manifestation of WGD was reported in triple-negative breast cancer, conferring high chromosomal instability (CIN), while HER2 + tumors exhibited early WGD events, with widely varied CIN levels, compared to luminal-type tumors. An association of higher activity of de novo indel signature 2 with WGD and HRD in Taiwanese breast cancer patients was reported. A control test between WGD and pseudo non-WGD samples was further employed to support this finding. The study provides a better comprehension of tumorigenesis in breast cancer subtypes, thus assisting in personalized treatment. © 2021, The Author(s).en[SDGs]SDG3adult; aged; breast tumor; classification; female; genetics; homologous recombination; human; human genome; middle aged; mutation; Taiwan; very elderly; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Female; Genome, Human; Homologous Recombination; Humans; Middle Aged; Mutation; Taiwanjournal article10.1038/s42003-021-02597-x345042922-s2.0-85114685446