BAI-CHIN LEEWEN-JENG LEEHsu H.-C.KUO-LIONG CHIENTIFFANY TING-FANG SHIHMING-FONG CHEN2020-08-052020-08-0520111569-5794https://scholars.lib.ntu.edu.tw/handle/123456789/511016We aimed to determine whether the Framingham risk score (FRS), systematic coronary risk evaluation (SCORE), and Chinese multi-provincial cohort study (CMCS) could predict anatomic severity of coronary plaques. From January 2007 to October 2010, we performed a contrast-enhanced 64-slice or 256-slice multidetector computed tomography coronary angiography as part of a health checkup protocol in 806 asymptomatic subjects (70.5% male, 56 ± 9 year-old). Risk scores significantly correlated with calcium volume score, plaque stenosis score and plaque distribution score (P<0.001). Of the 3 risk scores, the SCORE system showed the best correlation. Overall, 180 (22%) and 37 (5%) subjects were found to have stenosis of 50-69% and more than 70% in at-least one coronary artery segment, respectively. In the prediction of the presence of obstructive CAD (C50% diameter stenosis), all risk scores had similar discrimination. In the prediction of severe CAD (C70% diameter stenosis), FRS and CMCS had similar area under curves but SCORE discriminated better than FRS (P<0.05). The optimal cutoff point to predict obstructive CAD was 9.54% for FRS, 1.05% for CMCS, and 0.95% for SCORE, whereas to predict severe CAD was 9.63, 1.05, 1.15% for FRS, CMCS, SCORE, respectively, with a sensitivity of 0.61-0.70 and a specificity of 0.55-0.66. Cardiovascular risk scores are associated with the severity and extent of coronary artery plaque. The stronger association might translate into a better discrimination using SCORE. These findings will aid in the appropriate selection or recalibration of the risk assessment system for cardiovascular disease screening. ? 2011 Springer Science+Business Media, B.V.[SDGs]SDG3adult; aged; angiocardiography; article; Chinese; computed tomographic angiography; contrast enhancement; controlled study; coronary artery atherosclerosis; coronary artery obstruction; diagnostic accuracy; diagnostic imaging; disease severity; female; Framingham risk score; human; intermethod comparison; major clinical study; male; risk assessment; scoring system; sensitivity and specificity; systematic coronary risk evaluation; Adult; Aged; Aged, 80 and over; Asian Continental Ancestry Group; Asymptomatic Diseases; Chi-Square Distribution; China; Coronary Angiography; Coronary Stenosis; Female; Humans; Male; Middle Aged; Plaque, Atherosclerotic; Predictive Value of Tests; Risk Assessment; Risk Factors; Severity of Illness Index; Taiwan; Tomography, X-Ray Computed; Young Adultjournal article10.1007/s10554-011-9874-6216954852-s2.0-80054850608