Hsieh C.-H.Shueng P.-W.LI-YING WANGLiao L.-J.Lin Y.-C.Kuo Y.-S.Lo W.-C.Tseng C.-F.Tien H.-J.Chou H.-L.Hsieh Y.-P.Wu L.-J.Chen Y.-J.2020-06-292020-06-2920141178-6930https://www.scopus.com/inward/record.uri?eid=2-s2.0-84897903834&doi=10.2147%2fOTT.S59998&partnerID=40&md5=d620021f6291eed4e8e170e665261f24https://scholars.lib.ntu.edu.tw/handle/123456789/506303Background: The outcome of postoperative high- and intermediate-risk oral cavity cancer (OCC) patients receiving helical tomotherapy (HT) remains limited. Materials and methods: Between November 2006 and November 2012, 53 postoperative high- and intermediate-risk OCC patients treated with HT were enrolled. Results: The 4-year locoregional, local, and regional control rates were 66%, 76.4%, and 94.3%, respectively. The 4-year locoregional control rates of oral tongue and buccal mucosa cancer were 88.3% and 37.1%, respectively (P=0.012). Eleven (20.8%) patients experienced locoregional failure. In-field failure occurred in six of 53 (11.3%) in the primary area and three of 53 (5.7%) in the regional lymph-node area. No marginal failure was noted. Two of 53 (3.8%) experienced out-of-field failure. The rates of grade 3 dermatitis, mucositis, and dysphagia were 11%, 34%, and 13%, respectively. No grade 3 xerostomia was noted. Grade 2 xerostomia was 33% at month 6 and declined to 0 at month 48. A rate of 56% of grade 2 trismus at month 6 was noted, and declined to around 30% after 2 years. No grade 3 trismus was noted after 2 years. Conclusion: HT as a postoperative modality provided satisfying results, especially for xerostomia and trismus, and was impressive in high- and intermediate-risk OCC patients receiving postoperative HT. ? 2014 Hsieh et al.[SDGs]SDG3cisplatin; fluorouracil; folinic acid; adult; aged; anemia; article; cancer control; cancer radiotherapy; cheek mucosa; chemoradiotherapy; dysphagia; female; fistula; human; leukopenia; major clinical study; male; mouth squamous cell carcinoma; mucosa inflammation; oral surgery; photon therapy; postoperative care; radiation dermatitis; retrospective study; therapy effect; thrombocytopenia; tomotherapy; tongue cancer; treatment failure; trismus; xerostomiajournal article10.2147/OTT.S599982-s2.0-84897903834