Penfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statuses

Wu, Szu-YuanSzu-YuanWuWen, Yu-ChingYu-ChingWenCHIA-CHI KUYang, Yi-ChiehYi-ChiehYangChow, Jyh-MingJyh-MingChowYang, Shun-FaShun-FaYangLee, Wei-JiunnWei-JiunnLeeChien, Ming-HsienMing-HsienChien2020-08-142020-08-142019-08-311021-7770https://scholars.lib.ntu.edu.tw/handle/123456789/512840Chemotherapy is the main treatment for acute myeloid leukemia (AML), but the cure rates for AML patients remain low, and the notorious adverse effects of chemotherapeutic drugs drastically reduce the life quality of patients. Penfluridol, a long-acting oral antipsychotic drug, has an outstanding safety record and exerts oncostatic effects on various solid tumors. Until now, the effect of penfluridol on AML remains unknown.animationAcute myeloid leukemia; Akt; Apoptosis; Autophagy; Mitogen-activated protein kinase; Penfluridol; Protein phosphatase 2 a; Reactive oxygen speciesPenfluridol triggers cytoprotective autophagy and cellular apoptosis through ROS induction and activation of the PP2A-modulated MAPK pathway in acute myeloid leukemia with different FLT3 statusesjournal article10.1186/s12929-019-0557-2314708482-s2.0-85071759315WOS:000483570800002https://api.elsevier.com/content/abstract/scopus_id/85071759315https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071759315&doi=10.1186%2fs12929-019-0557-2&partnerID=40&md5=6978614e35ea9a0ae0a4a4930aa97b70