WEN-YEN CHIU2018-09-102018-09-102012http://www.scopus.com/inward/record.url?eid=2-s2.0-84862017888&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/370573This paper reports a novel method to synthesize magnetic, stimuli-sensitive latex nanoparticles made with magnetite/poly(N-isopropylacrylamide-co-acrylic acid) (Fe3O4/P(NIPAAm-co-AAc)). To form a stabilized suspended core, iron oxide (Fe3O4) was functionalized with AAc such that further polymerization with NIPAAm and AAc monomers could occur. The P(NIPAAm-co-AAc) shell layer exhibited thermosensitive properties. The inclusion of Fe3O4 into the latex nanoparticles was confirmed using transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction spectroscopy, thermogravimetric analyzer (TGA), and superconducting quantum interference device magnetometer. The NIP-(AAc2.6-Fe) latex nanoparticles contained 2.25% Fe3O4 (by weight), as determined by TGA analysis. The particle diameters measured approximately 160-240 nm with a lower critical solution temperature of 35°C. These novel magnetic stimuli-responsive latex nanoparticles have potential applications in numerous fields, such as catalyst supports, protein immobilization, cancer therapy, target drug delivery systems, and other biomedical applications. ? 2011 Elsevier Ltd. All rights reserved.Core-shell structure; N-Isopropylacrylamide[SDGs]SDG3Acrylic monomers; Amides; Carboxylic acids; High resolution transmission electron microscopy; Hydrogels; Iron oxides; Latexes; Magnetite; Magnetite nanoparticles; Medical applications; Nanomagnetics; Quantum interference devices; SQUIDs; Synthesis (chemical); Targeted drug delivery; Transmission electron microscopy; X ray diffraction; Biomedical applications; Core shell structure; Lower critical solution temperature; N- isopropylacrylamide; Protein immobilization; Superconducting quantum interference; Thermo-sensitive properties; Thermogravimetric analyzers; X ray photoelectron spectroscopyjournal article10.1016/j.polymer.2012.05.010