Antos, JoannaJoannaAntosWieczorek, DariaDariaWieczorekStaszak, KatarzynaKatarzynaStaszakChou, Yuk-PingYuk-PingChouHsu, Li-HangLi-HangHsuTANG-LONG SHENYING-LIEN CHEN2025-05-132025-05-132024-01-0127089967https://www.scopus.com/record/display.uri?eid=2-s2.0-85218451921&origin=recordpagehttps://scholars.lib.ntu.edu.tw/handle/123456789/729243Otilonium bromide is a cationic surfactant with established medical applications, revealing a promising dimension in its versatile nature. Beyond its conventional use, the compound demonstrates notable antifungal properties, signaling a substantial extension of its application potential. Due to the spreading drug resistance of many microorganisms to active substances and antibiotics, it is necessary to search for and create new compounds that will exhibit more aggressive mechanisms of action. Based on the methods of synthesis of otilonium bromide, new derivatives of the compound were created to broaden its applicability beyond its traditional pharmaceutical utility. Delving into the intricate synthesis processes employed, this study provides a detailed exploration of the newly created derivatives of otilonium bromide. The broadening of the applicability of otilonium bromide, especially in response to emerging challenges posed by microbial resistance, is intended to make a significant contribution to the evolving landscape of antimicrobial therapeutics. The findings not only unveil the expanded capabilities of otilonium bromide but also reveal new avenues for the development of compounds with enhanced efficacy and resilience in combating microbial threats.falseantifungal propertiescationic surfactantsdrugsotilonium bromidequaternary compoundsjournal article10.6180/jase.202510_28(10).00122-s2.0-85218451921