CHUN-JEN LIUCHIEN-CHING HUNGChen M.-Y.YO-PING LAIPEI-JER CHENHuang S.-H.DING-SHINN CHEN2021-06-072021-06-0720010192-0790https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984592179&doi=10.1097%2f00004836-200107000-00016&partnerID=40&md5=60ce3baef36f22f96f6fa072f22f1372https://scholars.lib.ntu.edu.tw/handle/123456789/565381Invasive amebiasis rarely occurs in homosexual men and human immunodeficiency virus (HIV)-infected individuals and has not been regarded as a beacon for concomitant HIV infection. We encountered a bisexual man with a protracted course of amebic liver abscess and amebic colitis. In the presence of fever, generalized lymphadenopathy, and elevated serum aminotransferase levels, HIV infection was suspected and then confirmed by a de novo seroconversion of HIV antibody. Subsequently, we noted two consecutive patients with amebic liver abscess, also later found to be infected with HIV. The ameba obtained from these three cases was identified as Entamoeba histolytica by amplification of 16S ribosomal RNA by polymerase chain reaction and direct sequencing. This observation suggests that amebic liver abscess and colitis can be presentations for HIV infection in the Far East. Thus, the local patients with invasive amebiasis, especially those with a protracted course or with risk factors of HIV infection, should be tested for HIV.[SDGs]SDG3aminotransferase; antibiotic agent; antivirus agent; ceftriaxone; diiodohydroxyquin; Human immunodeficiency virus antibody; indinavir; lamivudine; metronidazole; RNA 16S; vancomycin; zidovudine; adult; article; bisexuality; case report; clinical feature; dysentery; Entamoeba dispar; Entamoeba histolytica; fever; homosexuality; human; Human immunodeficiency virus; Human immunodeficiency virus infection; liver amebiasis; lymphadenopathy; male; polymerase chain reaction; priority journal; risk factor; RNA sequence; seroconversion; symptomjournal article10.1097/00004836-200107000-00016114187952-s2.0-84984592179