Chen, Yu-AnYu-AnChenLu, Chen-YuChen-YuLuWEN-FANG CHENGKUAN-TING KUOYu, Chen-WeiChen-WeiYuHONG-NERNG HOHSIN-FU CHENSZU-HUA PAN2022-10-282022-10-282022-09-101471-2407https://scholars.lib.ntu.edu.tw/handle/123456789/624147Ovarian cancer (OC) is the most lethal gynecological cancer due to the recurrence of drug-resistance. Cancer initiating cells (CICs) are proposed to be responsible for the aggressiveness of OC. The rarity and difficulty of in vitro long-term cultivation of CICs challenge the development of CIC-targeting therapeutics. Reprogramming cancer cells into induced cancer initiating cell (iCICs) could be an approach to solve these. Several inducible CICs have been acquired by activating the expression of stemness genes in different cancer cells. However, few reports have demonstrated the feasibility in OC.enCancer-initiating cells (CICs); Induced ovarian cancer-initiating cells (iOCICs); Organoid and drug screening; Ovarian cancer (OC)[SDGs]SDG3An experimental model for ovarian cancer: propagation of ovarian cancer initiating cells and generation of ovarian cancer organoidsjournal article10.1186/s12885-022-10042-3360850212-s2.0-85138126889WOS:000852443800001https://api.elsevier.com/content/abstract/scopus_id/85138126889