C-J KeT-Y SuH-ChenW-L ChiangP-C ChuY XiaH-W SungHAO-LI LIUC-J KeT-Y SuH-ChenW-L ChiangP-C ChuY XiaH-W Sung2020-10-072020-10-07201114337851https://www.scopus.com/inward/record.uri?eid=2-s2.0-80051776168&doi=10.1002%2fanie.201102852&partnerID=40&md5=46011160424b9d5643f8e5114b7db357Prepared to self-destruct: When poly(d,l-lactic-co-glycolic acid) (PLGA) hollow microspheres containing NaHCO3 entered the endocytic organelles of a live cell, the NaHCO3 in the aqueous core reacted with protons that infiltrated from the compartment to generate CO2 gas. The evolution of CO2 bubbles led to the formation of small holes in the PLGA shell and thus rapid release of the encapsulated drug doxorubicin (DOX; see picture). © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.controlled release; double emulsions; drug delivery; fluorescence; multifunctional particlesControlled release; Double emulsions; Doxorubicin; Encapsulated drugs; Hollow microsphere; Live cell; multifunctional particles; Poly(D , L-lactic-co-glycolic acid); Rapid release; Small Hole; Catalyst activity; Drug delivery; Microspheres; Carbon dioxide; bicarbonate; doxorubicin; drug; drug carrier; lactic acid; microsphere; polyglycolic acid; polylactic acid polyglycolic acid copolymer; polylactic acid-polyglycolic acid copolymer; article; cell survival; chemistry; drug effect; human; lysosome; metabolism; pH; tumor cell line; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Carriers; Humans; Hydrogen-Ion Concentration; Lactic Acid; Lysosomes; Microspheres; Pharmaceutical Preparations; Polyglycolic Acid; Sodium Bicarbonatejournal article10.1002/anie.2011028522-s2.0-80051776168