Mahdi A.Rutter E.M.Payne S.J.STEPHEN JOHN PAYNE2022-05-242022-05-242017https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021651254&doi=10.1016%2fj.medengphy.2017.06.007&partnerID=40&md5=cadc3393e982a7ab24823e14ec4eb700https://scholars.lib.ntu.edu.tw/handle/123456789/611753Cerebral autoregulation refers to the brain's regulation mechanisms that aim to maintain the cerebral blood flow approximately constant. It is often assessed by the autoregulation index (ARI). ARI uses arterial blood pressure and cerebral blood flow velocity time series to produce a ten-scale index of autoregulation performance (0 denoting the absence of and 9 the strongest autoregulation). Unfortunately, data are rarely free from various artefacts. Here, we consider four of the most common non-physiological blood pressure artefacts (saturation, square wave, reduced pulse pressure and impulse) and study their effects on ARI for a range of different artefact sizes. We show that a sufficiently large saturation and square wave always result in ARI reaching the maximum value of 9. The pulse pressure reduction and impulse artefact lead to more diverse behaviour. Finally, we characterized the critical size of artefacts, defined as the minimum artefact size that, on average, leads to a 10% deviation of ARI. ? 2017 IPEMBlood pressureBlood vesselsHemodynamicsPhysiologyTissueArterial blood pressureAutoregulationsCerebral autoregulationCerebral blood flowCerebral blood flow velocitiesCritical sizePulse pressureRegulation mechanismsBrainarterial pressureArticleartifactartifact reductionautoregulationautoregulation indexbrain blood flowbrain functioncerebral autoregulationcontrolled studyhumanhuman experimentmedical parametersnormal humanpriority journalpulse pressureblood flow velocityblood pressureblood pressure measurementbrain circulationevaluation studyhomeostasisphysiologyproceduresreproducibilitysensitivity and specificityArtifactsBlood Flow VelocityBlood PressureBlood Pressure DeterminationCerebrovascular CirculationHomeostasisHumansReproducibility of ResultsSensitivity and Specificity[SDGs]SDG3journal article10.1016/j.medengphy.2017.06.0072-s2.0-85021651254