Singh, SanjaySanjaySinghJANN-YUAN WANGHeysell, Scott KScott KHeysellMcShane, Pamela JPamela JMcShaneWadle, CarlyCarlyWadleShankar, PremPremShankarHuang, Hung-LingHung-LingHuangPasipanodya, JotamJotamPasipanodyaBoorgula, Gunavanthi DGunavanthi DBoorgulaPhilley, Julie VJulie VPhilleyGumbo, TawandaTawandaGumboSrivastava, ShashikantShashikantSrivastava2023-09-052023-09-052023-0709248579https://scholars.lib.ntu.edu.tw/handle/123456789/635052Guideline-based therapy (GBT) for pulmonary Mycobacterium abscessus (Mab) disease achieves sustained sputum culture conversion (SSCC) rates of 30%; this is reflected by poor efficacy of GBT in the hollow fiber system model of Mab (HFS-Mab), which killed ∼1.22 log10 CFU/mL. This study was performed to determine which clinical dose of omadacycline, a tetracycline antibiotic, should be used in combination therapy to treat pulmonary Mab disease for relapse-free cure.enEfficacy; Hollow fiber system model; M. abscessus; Pharmacokinetics/pharmacodynamics; Safetyjournal article10.1016/j.ijantimicag.2023.106847371873382-s2.0-85161273019https://api.elsevier.com/content/abstract/scopus_id/85161273019