Large-scale synthesis of per-O-acetylated saccharides and their sequential transformation to glycosyl bromides and thioglycosides

Lin, Chan ChingChan ChingLinHuang, Li ChengLi ChengHuangPI-HUI LIANGLiu, Ching YangChing YangLiuLin, Chun ChengChun ChengLin2024-03-262024-03-262006-06-0107328303https://scholars.lib.ntu.edu.tw/handle/123456789/641359This work describes a large-scale synthesis of per- O -acetylated mono- and disaccharides using a stoichiometric amount of acetic anhydride in the presence of LiClO 4 under solvent-free conditions. The peracetylated saccharides underwent subsequent anomeric bromination and thioglycosidation in one-pot to yield synthetically valuable building blocks. Copyright © Taylor & Francis Group, LLC.Acetylation | Glycosyl bromides | LiClO 4 | One-pot synthesis | ThioglycosidesLarge-scale synthesis of per-O-acetylated saccharides and their sequential transformation to glycosyl bromides and thioglycosidesjournal article10.1080/073283006007704692-s2.0-33745782520https://api.elsevier.com/content/abstract/scopus_id/33745782520