臺大醫院;臺大醫院-內科部;臺大醫學院;臺大醫學院-藥理學科暨研究所;Chen, Mei-ChuanMei-ChuanChenCHE-MING TENGChen, Chun-HanChun-HanChenLiu, Yi-NanYi-NanLiuWang, Hui-PoHui-PoWangPan, Shiow-LinShiow-LinPanTeng, Che-MingChe-MingTeng2018-09-102018-09-102013http://www.scopus.com/inward/record.url?eid=2-s2.0-84879785179&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/376491Here, we report that TW01001, a novel piperazinedione compound, could be a new mitotic inhibitor for the treatment of non-small cell lung cancer by the following observations in A549 cells: (1) induction of cells to accumulate at G2/M phase, which ultimately led to cell apoptotic death, (2) accumulation of p53 and inhibition of survival signalings, and (3) induction of p53-independent autophagy. Taken together, our data suggested that TW01001 induces autophagy-p53-signaling pathway to cause mitotic arrest and cell growth inhibition in A549 cells and provides the framework for further development as a novel therapeutic agent for lung cancer treatment. ? 2013 Elsevier Ireland Ltd.110 bytestext/htmlApoptosis; Autophagy; Lung cancer; Mitotic arrest; Signal transduction[SDGs]SDG3actin; aurora A kinase; aurora B kinase; cyclin B1; cyclin dependent kinase 1; piperazinedione; polo like kinase 1; protein p53; small interfering RNA; tw 01001; unclassified drug; antineoplastic activity; apoptosis; article; autophagy; cancer cell culture; cancer inhibition; cell cycle G2 phase; cell cycle M phase; cell survival; controlled study; drug structure; human; human cell; inhibition kinetics; lung non small cell cancer; mitosis inhibition; priority journal; signal transduction; Autophagy; Benzoates; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Division; Cell Line, Tumor; Diketopiperazines; G2 Phase; Humans; Lung Neoplasms; Mitosis; Piperazines; Signal Transductionjournal article10.1016/j.canlet.2013.03.028