2013-01-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/678572摘要：脂肪肝迷你豬動物模式之建立<br> Abstract: Fatty liver disease is one of the most common causes of chronic liver disease in the world. Hepatic steatosis is present in up to one third of the Taiwan population and other developed countries. The etiopathogenic factors are diverse and include alcohol intoxication, obesity, diabetes mellitus, insulin resistance, viral, chemical toxic or metabolism disorder. Fatty liver (steatohepatosis) is the earliest stage of many chronic liver diseases. In patients with hepatic steatosis, lipid accumulates in lipid droplets within hepatocytes. Patients with alcoholic (ASH) or non-alcoholic (NASH) fatty liver play an important role in clinical medicine. One can easily recognize that there is an enormous need for alcoholic or non-alcoholic research in gastroenterology to develop more effective strategies to prevent and treat the different kinds of fatty liver disease. Additionally, a considerable number of open questions remain in the field of fatty liver disease research; among them important issues include the pathophysiology of alcohol/or high-fat diet induced hepatocyte damage, the action of the hepatic metabolism disorder and gene expression. Animal models have been employed to mimic the human situation and to simplify studies on the effects of drugs on the alcoholic/or high-fat induced fatty liver disease animal model. With the establishment of an ideal fatty liver disease animal model, in the previous year, we have been accomplished the follow two ASH/and NASH animal models. With the long term goal of a full understanding of the pathophysiologic mechanism by which factors cause the fatty liver disease and of developing therapeutic strategies for fatty liver disease, forms of alcoholic and non-alcoholic fatty liver, in past 3 years, we attempt to accomplish the following three specific aims during 3 years. We identify and monitor the function and expression of hepatocyte genes during development of alcoholic and non-alcoholic fatty liver disease. Secondary, we access the effect related drug on fatty liver development and progression and to access the therapeutic effect of herbal flavonoids and polysaccharides and to uncover the molecular mechanism underlying their therapeutic effects on fatty liver disease.迷你豬脂肪肝高脂飼糧動物模式mini-pigFatty liverHigh-fat DietAnimal Model