LI-TA KENGLin, Chen-ChiehChen-ChiehLinWu, Chang-WeiChang-WeiWuChen, Jung-YuehJung-YuehChenCHIA-JUNG LIULIH-YU CHANGMENG-RUI LEEJANN-YUAN WANG2024-11-252024-11-252024-11-06https://scholars.lib.ntu.edu.tw/handle/123456789/723228-specific IgG is often used as a diagnostic test for chronic pulmonary aspergillosis (CPA), but few studies have evaluated the performance and serology of IgGs from species other than . In this study, we evaluated the serology and performance of different species-specific IgG antibodies in patients with CPA and at-risk populations and whether different species-specific IgGs could be of clinical utility and aid in the diagnosis of CPA caused by all . A total of 187 participants were included between 2020 and 2022 (12 with CPA, 75 with old tuberculosis [TB], 45 with active TB and 55 with bronchiectasis). We measured the serum , -specific, and mixed IgG levels (Phadia ImmunoCap). The correlation was the strongest between and (Spearman's rank: 0.940), followed by and (Spearman's rank: 0.915). -specific IgG was less strongly correlated with the other three species-specific IgG (Spearman's rank: 0.828-0.849). (4 of 6, 67%) was the dominant species. Using the at-least-one-positive approach, the highest performance was obtained when and IgGs were used (sensitivity, 0.75; specificity, 0.84). Significant cross-reactivity exists among different species IgGs although the correlation may be less significant for . In addition to the commonly used IgG test, IgGs specific to local prevalent species may provide additional clinical utility.enAspergillus IgGAspergillus flavusAspergillus fumigatusAspergillus nigerAspergillus terreuschronic pulmonary aspergillosis[SDGs]SDG3journal article10.1080/20477724.2024.242448939504999