2016-01-012024-05-14https://scholars.lib.ntu.edu.tw/handle/123456789/657573Abstract: This proposal is based on a collaboration of nine professors, lead and supervised by University President Yang. Our major goal is to print human tissues, including the blood vessel, the trachea, and the bone. First, using the novel biodegradable compliant water-based printing materials developed by Prof. Hsu, strong mechanical engineering professors who is familiar with CAD/CAM, Prof. Yen and Professor Chung, will work together with her to print the blood vessel and trachea (without cells). Constructs will be printed from FDM and LFDM 3D printing platforms based on the medical images obtained by Prof. Ni and Prof. Tsao. As we know that mechanical properties are critical for blood vessel to function, Prof. Wang will then assess the biomechanical properties of these constructs. After that, Prof. Hsu, Prof. Ni, and Prof. Tsao will culture cells on the constructs. The bio-3D printed constructs will be again evaluated for the biomechanical properties. Subsequently, these 3D constructs will be implanted into animal models provided by Prof. Ni and Prof. Tsao in order to evaluate the functionality of these bio-3D printing constructs. Besides, Prof. Liao will work on using SLS 3D printing platform to print bone. Prof. Chang and Prof. Lin will be in charge of culturing cells and animal models, each related to orthopedics and dental applications. We aim to eventually translate these technologies to clinical applications. With the strong interdisciplinary collaboration efforts from the medical doctors and engineering professors, we believe the research outcome will be not only high-impact publication, but also technology transfer. With the strong collaboration between the faculties of colleges of engineering and medicine, we believe that by the end of the project term, the NTU team will be able to lead the bio-3D printing industry and create personalized and customized regenerative medicine based on 3D printing technology in Taiwan as well as globally.3D printingtissue printingvascularregenerative medicine