2020-03-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/672819摘要：本子計畫三係利用子計畫一與子計畫二所開發可調變波長之塔米電漿子雷射光源於前一年臺灣大學聯盟團隊成員合作發展之隨機雷射開發散斑對比成像系統(laser speckle contrast imaging, LACI)上。於前一年計畫中雖我們發展出利用隨機雷射作為雷射散斑系統光源並且初步驗證其於活體量測血管分佈之可行性，但是所使用之隨機雷射其光源強度過低且只能作為點光源使用，對於LACI系統之血管成像以及血氧資訊分析上之訊噪比有所侷限。因此、此一子計畫將透過使用可同時產生多點且多波長輸出之塔米電漿子雷射光源進一步改善前述成像系統侷限。此外、將透過光源於製程過程中之特殊設計，以達成多點照明，以獲取具有較高時間解析度之血氧代謝資訊。最後、我們亦將進一步整合本子計畫團隊所自行開發利用光學同調血管攝影術之成像平台與前述塔米雷射散班係成像系統以進行兩套系統所提供之血氧資訊以及三微微血管結構分布間之交互驗證。<br> Abstract: Subproject 3 was based on the multi-wavelength Tamm plasmon laser as well as the laser speckle contrast imaging (LACI) using the random laser developed in the previous funding period through the collaboration among the PIs in these three subjects. Though we have the LACI imaging system with the random laser and has validated the performance of the light source developed accordingly, the laser output power is low and can be only be operated as a point source. These limitations make the vascular imaging with the LACI imaging system in combination with the random laser challenging, particularly, the signal to noise ratio. Therefore, in this subproject, we aim to develop a vascular imaging system with a higher temporal resolution by using the multi-point illumination leveraging the intricate design of the light source. Lastly, we will integrate the aforementioned vascular imaging system with the in house developed optical coherence tomography angiography imaging system to provide the validation of microvascular information identified in either system.生醫光電血氧量測雷射散斑影像塔米電漿子雷射Biophotonicsblood oxygenation measurementlaser speckle imagingTamm plasmon exciton-polariton laser