Mo Y.-H.YA-FANG CHENHON-MAN LIU2020-09-232020-09-2320040028-3940https://scholars.lib.ntu.edu.tw/handle/123456789/514712Adrenomyeloneuropathy (AMN) is a phenotype variant of X-linked adrenoleukodystrophy. We present two patients with adult-onset AMN who were initially suspected to have demyelinating disorders radiologically and finally diagnosed on the basis of laboratory data. The brain magnetic resonance images showed abnormal signal intensity at pyramidal tracts and cerebellar hemisphere bilaterally with abnormal enhancement after contrast medium administration. Review of the literature shows that the brain magnetic resonance findings of adrenomyeloneuropathy may include normal brain, tract demyelination, white matter demyelination, or brain atrophy. Disease progression was demonstrated by follow-up imaging. ? Springer-Verlag 2004.[SDGs]SDG3corticosteroid; adrenoleukodystrophy; adult; brain atrophy; brain region; case report; cerebellum; contrast enhancement; demyelinating disease; disease course; follow up; hemisphere; human; image analysis; laboratory test; male; nerve tract; nuclear magnetic resonance imaging; phenotypic variation; priority journal; pyramidal tract; radiodiagnosis; review; signal transduction; white matter; X chromosome linked disorder; Adrenoleukodystrophy; Adult; Age of Onset; Brain; Demyelinating Diseases; Diagnosis, Differential; Disease Progression; Humans; Magnetic Resonance Imaging; Malereview10.1007/s00234-003-1096-8150075752-s2.0-2342486047