CHIN-HSIAO TSENGChong C.-K.Tseng C.-P.Shau W.-Y.TONG-YUAN TAI2020-06-012020-06-0120081346-9843https://www.scopus.com/inward/record.uri?eid=2-s2.0-50449110473&doi=10.1253%2fcircj.CJ-08-0009&partnerID=40&md5=aed151f7b39cab7061c9ae405c61c939https://scholars.lib.ntu.edu.tw/handle/123456789/496166Background: To evaluate the association between components of metabolic syndrome (MS) and ischemic heart disease (IHD) in Taiwanese patients with type 2 diabetes mellitus (T2DM). Methods and Results: A total of 1,296 (604 men and 692 women) subjects with T2DM aged 62.5±11.7 (14-87) years were studied. MS was defined using the World Health Organization modified criteria and included more than 2 of hypertension, obesity, dyslipidemia and microalbuminuria. IHD was diagnosed through history or ischemic electrocardiogram according to the Minnesota codes. Results showed that MS was present in 76.2% and IHD in 36.3% of the patients, respectively. MS increased with age for both sexes, but there was no difference between men and women in the age groups of <45, 45-54 and 55-64 years. However, the prevalence of MS was significantly higher in women (87.7% vs 78.0%) in the age group ?65 years. IHD prevalence was significantly higher in patients with MS, hypertension, dyslipidemia and obesity (p<0.01), and was higher with borderline significance for microalbuminuria (0.05<p<0.1). The respective age-adjusted odds ratios were 3.61 (2.57-5.08), 7.10 (5.38-9.38), 1.70 (1.32-2.18), 1.75 (1.33-2.28), and 1.11 (0.88-1.41). Conclusions: The prevalence of MS in subjects with T2DM is high and increases with age. The impact of different risk factors on IHD is diverse, with hypertension being the most important.[SDGs]SDG3adolescent; adult; age distribution; aged; article; cardiovascular risk; disease association; dyslipidemia; electrocardiogram; female; human; hypertension; ischemic heart disease; major clinical study; male; metabolic syndrome X; microalbuminuria; non insulin dependent diabetes mellitus; obesity; prevalence; statistical significance; Taiwan; world health organization; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Asian Continental Ancestry Group; Diabetes Complications; Diabetes Mellitus, Type 2; Electrocardiography; Female; Humans; Hypertension; Male; Metabolic Syndrome X; Middle Aged; Myocardial Ischemia; Prevalence; Risk Factors; Sex Factors; Taiwanjournal article10.1253/circj.CJ-08-0009187240152-s2.0-50449110473