2012-08-012024-05-18https://scholars.lib.ntu.edu.tw/handle/123456789/704440Background: With the increasing age of patients, the roles of environmental factors have become more important. Chemoprevention is not only a hypothesis, but also gradually becomes a feasible way to prevent gastric cancer. Aims: 1. Systematically screen potentially useful drugs for gastric cancer chemoprevention. 2. Investigate the cell biology functions in vitro and in vivo. 3. Integrate host and environmental factors to develop nomogram to predict gastric cancer. Study subjects and methods: NHIRD research: 1. Systematically screen potentially useful drugs for gastric cancer chemoprevention 2. Investigate the potential interaction between the identified drugs with other host and environmental factors, such as gene, smoking, diet, H. pylori¸ etc. 3. Calculate NTT, optimal duration and dose for chemoprevention 4. Stratify patients’ risk for developing gastric cancer according to the drugs they use In vitro and in vivo studies: 1. Investigate the cell biology functions of the identified drugs in gastric carcinogenesis 2. Study how these drugs inhibit gastric cancer tumor growth, invasion and metastasis in animal model 3. Analyze how the identified drugs influence proteins in the related pathways. Clinical studies: 1. Integrate demographic data, phenotypes, environmental factors, chemopreventive drugs, family history, co-morbidities, and other laboratory data in the prediction model. 2. Construct nomogram for predicting gastric cancer risk for individual patients 3. Establish personalized chemopreventive strategies. Expected contributions: This project will provide valuable results for scientists who are interested to find new drugs to prevent or to treat gastric cancer. It also provides physician an assessment tool to predict gastric cancer development according to stratified risk stratification. For patients, personalized chemoprevention strategies will be available to prevent gastric cancer.