2007-11-012024-05-15https://scholars.lib.ntu.edu.tw/handle/123456789/666096摘要：本計畫將發展創新之微液珠操控技術並落實於生醫診測元件之設計，開發快速檢測裝置，以利於生活中即時監控身體狀況並早期篩檢重要病徵，防範疾病於未然、於症狀之初始。如此，得以減少整體醫療負擔，優化生活品質。並促進慢性病患者及老年人口之健康照護，本計畫初期（1～3 年）將致力於核心技術開發，製作具親疏水性梯度的表面，進而發展利用電磁場調控之表面能，並整合於檢測系統之原型機。中長期階段(4 至15 年)欲開發出攜帶式 檢測PDA，能即時進行身體狀況監測，此外，相關技術亦能輔助或整合至醫療機構的檢測儀器及臨床診斷，達成快速檢測、精確定量之目的。因此，本計畫不僅將開發新穎技術，更將整合奈微機電系統、生命科學、醫學、化學等領域轉譯（translate）為臨床應用。其中，以體液為檢體藉由超順磁奈米粒子與生物分子自組裝技術於待檢分子之純化。而奈微流體操控直接運用於DNA 及生化分子之定性及定量量測，文獻中尚未曾發表過。未來無論在簡易身體狀況及時檢測之模組開發、居家自我監測、以及醫療單位的快速精準檢測皆有極大之發展空間。總之，本計畫不僅具有卓越之創新構想與技術整合，未來的發展亦將能貢獻於全球漸漸形成之老年化人口及醫療問題。創造更舒適之生活環境。<br> Abstract: This project aims to develop a novel technology for micro/nano droplet manipulation and apply for efficient and accurate biomedical detections. The developed technology will enable real-time monitoring of health status and early detection of minor clinical symptoms and signs so that diseases can be screened and diagnosed at their earliest stage. In such a way, the overall health care budget could be significantly reduced and the life quality could be promoted. These will obviously contribute to a global trend of growing aged population and chronic disease patients. In the first phase (the first three years) of the project development, we will focus on the design and implementation of core technologies. These include the fabrication and manipulation of surfaces with controlled gradient of surface energy, the precise electromagnetic field manipulation of fluid transport, and the system integration. The mid-term phase will develop portable detection device with integrated medical informatics and wireless Med-link system. The device will be able to track biological index constantly and to extend their information to the global Med-link and HIS system of regional medical care unit and/or hospital. Besides, the associated technology will en-power clinical diagnosis through parametric analysis for rapid and accurate decision making to fulfill advanced custom based medical care. Therefore, current project will not only acquire significant novel technology platforms, but also demonstrate a comprehensive integration of micro/nano technology, life science, medicine, and chemistry for a successful translation into clinical application. Within the scope, biomolecules to be detected will be extracted and concentrated from the body fluid through self-assembly ligand or oligonucleotide conjugated superparamagnetic nanoparticles. The derived droplet will be directed for transportation qualification and quantification measurement by droplet motility that has not been reported in the literature. Thus the current platform will have a wide spectrum of future applications for rapid portable health monitor module, point-of-care device, at-home health consoler, and medical center bed-side wireless health detection unit. In summary, this project presents outstanding innovative idea and technology integration for an expected contribution to a global trend of aging society and health care economics for human wellbeing.微液珠操控生化分子自組裝電/磁場可調控生化分子薄膜居家篩檢快速臨microdroplet manipulationbiomolecule self-assemblyelectromagnetic fieldcontrollable biomolecular filmpoint-of-at-carerapid clinical detectionbiochip