Lee, Yi-HsuanYi-HsuanLeeHuang, Chung-YenChung-YenHuangHsieh, Yu-HanYu-HanHsiehYang, Chia-HungChia-HungYangHung, Yu-LingYu-LingHungChen, Yung-AnYung-AnChenLin, Yu-ChiehYu-ChiehLinCHING-HUNG LINJIH-HSIANG LEEWang, Ming-YangMing-YangWangWEN-HUNG KUOLin, Yen-YinYen-YinLinYEN-SHEN LU2024-02-052024-02-052024-12-011471-2407https://scholars.lib.ntu.edu.tw/handle/123456789/639614Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) are the two most common immune checkpoints targeted in triple-negative breast cancer (BC). Refining patient selection for immunotherapy is non-trivial and finding an appropriate digital pathology framework for spatial analysis of theranostic biomarkers for PD-1/PD-L1 inhibitors remains an unmet clinical need.enBreast cancer; Immunofluorescence staining; Optical clearing; Programmed death-ligand 1; Three-dimensional imagingA novel computer-assisted tool for 3D imaging of programmed death-ligand 1 expression in immunofluorescence-stained and optically cleared breast cancer specimensjournal article10.1186/s12885-023-11748-8382679032-s2.0-85183032793https://api.elsevier.com/content/abstract/scopus_id/85183032793