Blechter, BatelBatelBlechterHsiung, Chao AgnesChao AgnesHsiungWang, XiaoyuXiaoyuWangZhang, HaoyuHaoyuZhangSeow, Wei JieWei JieSeowShi, JianxinJianxinShiChatterjee, NilanjanNilanjanChatterjeeKim, Hee NamHee NamKimWong, Maria PikMaria PikWongHong, Yun-ChulYun-ChulHongWong, Jason Y YJason Y YWongDai, JunchengJunchengDaiHosgood, H DeanH DeanHosgoodWang, ZhaomingZhaomingWangChang, I-ShouI-ShouChangChoi, JiyeonJiyeonChoiWang, JiucunJiucunWangSong, MinsunMinsunSongHu, WeiWeiHuZheng, WeiWeiZhengKim, Jin HeeJin HeeKimZhou, BaosenBaosenZhouAlbanes, DemetriusDemetriusAlbanesShin, Min-HoMin-HoShinChung, Lap PingLap PingChungAn, She-JuanShe-JuanAnZheng, HongHongZhengYatabe, YasushiYasushiYatabeZhang, Xu-ChaoXu-ChaoZhangKim, Young TaeYoung TaeKimShu, Xiao-OuXiao-OuShuKim, Young-ChulYoung-ChulKimVermeulen, Roel C HRoel C HVermeulenBassig, Bryan ABryan ABassigChang, JiangJiangChangMan Ho, James ChungJames ChungMan HoJi, Bu-TianBu-TianJiKubo, MichiakiMichiakiKuboDaigo, YataroYataroDaigoMomozawa, YukihideYukihideMomozawaKamatani, YoichiroYoichiroKamataniHonda, TakayukiTakayukiHondaKunitoh, HideoHideoKunitohWatanabe, Shun-IchiShun-IchiWatanabeMiyagi, YoheiYoheiMiyagiNakayama, HaruhikoHaruhikoNakayamaMatsumoto, ShingoShingoMatsumotoTsuboi, MasahiroMasahiroTsuboiGoto, KoichiKoichiGotoYin, ZhihuaZhihuaYinTakahashi, AtsushiAtsushiTakahashiGoto, AkiteruAkiteruGotoMinamiya, YoshihiroYoshihiroMinamiyaShimizu, KimihiroKimihiroShimizuTanaka, KazumiKazumiTanakaWu, TangchunTangchunWuWei, FushengFushengWeiSu, JianJianSuKim, Yeul HongYeul HongKimOh, In-JaeIn-JaeOhFun Lee, Victor HoVictor HoFun LeeSu, Wu-ChouWu-ChouSuChen, Yuh-MinYuh-MinChenChang, Gee-ChenGee-ChenChangKUAN-YU CHENHuang, Ming-ShyanMing-ShyanHuangLin, Hsien-ChihHsien-ChihLinSeow, AdelineAdelineSeowPark, Jae YongJae YongParkKweon, Sun-SeogSun-SeogKweonChen, Chien-JenChien-JenChenGao, Yu-TangYu-TangGaoWu, ChenChenWuQian, BiyunBiyunQianLu, DaruDaruLuLiu, JianjunJianjunLiuJeon, Hyo-SungHyo-SungJeonHsiao, Chin-FuChin-FuHsiaoSung, Jae SookJae SookSungTsai, Ying-HuangYing-HuangTsaiJung, Yoo JinYoo JinJungGuo, HuanHuanGuoHu, ZhibinZhibinHuChen, Tzu-YuTzu-YuChenBurdett, LaurieLaurieBurdettYeager, MeredithMeredithYeagerHutchinson, AmyAmyHutchinsonBerndt, Sonja ISonja IBerndtWu, WeiWeiWuWang, JunwenJunwenWangChoi, Jin EunJin EunChoiPark, Kyong HwaKyong HwaParkSung, Sook WhanSook WhanSungLiu, LiLiLiuKang, Chang HyunChang HyunKangChen, Chung-HsingChung-HsingChenXu, JunJunXuGuan, PengPengGuanTan, WenWenTanWang, Chih-LiangChih-LiangWangLoon Sihoe, Alan DartAlan DartLoon SihoeChen, YingYingChenChoi, Yi YoungYi YoungChoiKim, Jun SukJun SukKimYoon, Ho-IlHo-IlYoonCai, QiuyinQiuyinCaiPark, In KyuIn KyuParkXu, PingPingXuHe, QinchengQinchengHeChen, Chih-YiChih-YiChenWu, JunjieJunjieWuLim, Wei-YenWei-YenLimChen, Kun-ChiehKun-ChiehChenChan, John K CJohn K CChanLi, JihuaJihuaLiChen, HongyanHongyanChenCHONG-JEN YUJin, LiLiJinFraumeni, Joseph FJoseph FFraumeniLiu, JieJieLiuLandi, Maria TeresaMaria TeresaLandiYamaji, TaikiTaikiYamajiYang, YangYangYangHicks, BelyndaBelyndaHicksWyatt, KathleenKathleenWyattLi, Shengchao AShengchao ALiMa, HongxiaHongxiaMaSong, BaoBaoSongWang, ZhehaiZhehaiWangCheng, SensenSensenChengLi, XuelianXuelianLiRen, YangwuYangwuRenIwasaki, MotokiMotokiIwasakiZhu, JunjieJunjieZhuJiang, GeningGeningJiangFei, KeKeFeiWu, GuopingGuopingWuChien, Li-HsinLi-HsinChienTsai, Fang-YuFang-YuTsaiYu, JinmingJinmingYuStevens, Victoria LVictoria LStevensPAN-CHYR YANGLin, DongxinDongxinLinChen, KexinKexinChenWu, Yi-LongYi-LongWuMatsuo, KeitaroKeitaroMatsuoRothman, NathanielNathanielRothmanShiraishi, KouyaKouyaShiraishiShen, HongbingHongbingShenChanock, Stephen JStephen JChanockKohno, TakashiTakashiKohnoLan, QingQingLan2025-01-202025-01-202025https://scholars.lib.ntu.edu.tw/handle/123456789/724932We assessed the association between a genome-wide polygenic risk score (PRS) developed for lung adenocarcinoma (LUAD) risk and mutation on the EGFR gene in 998 East Asian never-smoking female LUAD cases (518 EGFR-positive; 480 EGFR-negative) and 4544 never-smoking controls using case-case and multinomial regression analyses. We found that the PRS was more strongly associated with EGFR-positive LUAD compared with EGFR-negative LUAD, where the association between the fourth quartile of the PRS and EGFR-positive LUAD (odds ratio = 8.63, 95% confidence interval: 5.67-13.14) was significantly higher than the association between the fourth quartile of the PRS with EGFR-negative LUAD (odds ratio = 3.50, 95% confidence interval: 2.44-5.00) (p-heterogeneity = 3.66 × 10). Our findings suggest that germline genetic susceptibility may be differentially associated with LUAD in never-smoking female East Asian patients depending on the cancer's mutation status, which may have important public health and clinical implications.enEGFR mutationLung adenocarcinomaNever-smokersPolygenic risk score[SDGs]SDG3journal article10.1016/j.jtho.2024.11.01939581378