High frequency of heat shock protein 27 overexpression is a highly effective, high-coverage marker for minimal residual disease detection in children with B-cell acute lymphoblastic leukemia

SHU-WEI CHOUSu, Ying-HuiYing-HuiSuMENG-YAO LUHSIU-HAO CHANGYUNG-LI YANGLin, Dong-TsamnDong-TsamnLinLin, Kai-HsinKai-HsinLinCoustan-Smith, ElaineElaineCoustan-SmithSHIANN-TANG JOU2023-01-112023-01-112023-011545-5009https://scholars.lib.ntu.edu.tw/handle/123456789/627170Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Minimal residual disease (MRD) detection is the most powerful prognostic tool for monitoring treatment efficacy and predicting clinical outcomes. We aimed to identify key leukemia-associated markers, the proportions of differential expression in patients, and the most effective marker combination for MRD detection by flow cytometry.enacute lymphoblastic leukemia; flow cytometry; leukemia-associated markers; minimal residual disease; pediatrics[SDGs]SDG3High frequency of heat shock protein 27 overexpression is a highly effective, high-coverage marker for minimal residual disease detection in children with B-cell acute lymphoblastic leukemiajournal article10.1002/pbc.29990362509962-s2.0-85140000604WOS:000868754200001https://api.elsevier.com/content/abstract/scopus_id/85140000604