Chen B.-Y.CHI-HSIEN CHENPAU-CHUNG CHENGEN-SHUH WANGYue Leon Guo2020-03-102020-03-1020131680-8584https://www.scopus.com/inward/record.uri?eid=2-s2.0-84888398224&doi=10.4209%2faaqr.2012.11.0299&partnerID=40&md5=da06f5c3ec3c773176596ec2cad1d1f6https://scholars.lib.ntu.edu.tw/handle/123456789/475235Background: Alterations in allergic susceptibility are a central feature of several chronic respiratory diseases. This study was conducted to determine whether variation in individual allergic susceptibility alters the air pollution effects on attacks of pediatric asthma. Methods: Daily records of personal asthma emergency department visits among children in school-age and ambient air pollutant concentration were obtained from 2000 to 2008 in Taipei basin, Taiwan. Subjects who had ever had a clinical visit in the departments of otolaryngology and pediatrics or a visit to the emergency department due to allergic rhinitis before their first asthma-related emergency department visit were defined as having allergic rhinitis co-morbidities. A time-stratified approach for the case-crossover technique and a conditional logistic regression were used to examine whether allergic comorbidity modified air pollution-induced asthma attacks. Results: Particulate matter with an aerodynamic diameter of 2.5 μm or less (PM2.5) was found to be associated with asthma-related emergency department visits on the day of exposure among children with allergic rhinitis co-morbidity (2nd quartile OR = 1.19; 3rd quartile OR = 1.37; 4th quartile OR = 1.38). High ozone levels were associated with emergency room visits for asthma on a 1-day lag assumption among children with allergic rhinitis co-morbidity (4th quartile OR = 1.38). Conclusion: The negative effects of air pollution were observed for subjects who had an allergic co-morbidity. The variation in allergic co-morbidity was associated with differences in susceptibility to the adverse effects of air pollutants on respiratory disease. ? Taiwan Association for Aerosol Research.[SDGs]SDG3Aerodynamic diameters; Air pollution effects; Allergic rhinitis; Asthma; Co morbidities; Conditional logistic regressions; Emergency departments; Emergency room visits; Emergency rooms; Pediatrics; Pulmonary diseases; Air pollution; allergy; asthma; atmospheric pollution; child health; morbidity; pollution effect; pollution exposure; regression analysis; Taipei Basin; Taiwanjournal article10.4209/aaqr.2012.11.02992-s2.0-84888398224