Weng, W.-C., Lee, W.-T., Hsu, W.-M., Chang, B.-E., Lee, H.W.-C., Lee, W.-T., Hsu, W.-M., Chang, B.-E., Lee, H.WengWANG-TSO LEEWEN-MING HSUBEI-EN CHANGHSINYU LEE2020-03-052020-03-0520110929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-79960803788&doi=10.1016%2fS0929-6646%2811%2960064-8&partnerID=40&md5=7166cd287e331d55b3286ae6527583afhttps://scholars.lib.ntu.edu.tw/handle/123456789/470021Glucose-regulated protein 78 (GRP78) is an important chaperone protein that is predominantly expressed in the endoplasmic reticulum. The multifunctional roles of GRP78 in protein folding, endoplasmic reticulum calcium binding, cytoprotection, and anti-apoptosis, as well as its function as a receptor on the cell surface, disclose its major involvement in physiological and numerous pathological conditions. Recent advances in mouse models targeting GRP78 allele have revealed the essential roles of GRP78 in development and neurological disorders, as well as accurate neural migration and neuroprotection. This review of correlation between GRP78 and embryogenesis and neurological disorders provides further directions for investigation, as well as potential therapeutics for clinical use. ? 2011 Elsevier & Formosan Medical Association.[SDGs]SDG3activating transcription factor 4; activating transcription factor 6; biological marker; calnexin; calreticulin; glucose regulated protein 78; glucose regulated protein 94; growth arrest and DNA damage inducible protein 34; nerve growth factor; protein IRE1; small interfering RNA; temozolomide; transcription factor; unclassified drug; valproic acid; X box binding protein 1; 5' untranslated region; Alzheimer disease; amyotrophic lateral sclerosis; apoptosis; autophagosome; bipolar disorder; blastocyst; brain ischemia; breast cancer; calcium binding; cancer growth; cancer invasion; cell proliferation; cell protection; cell surface; cerebellum atrophy; embryo development; endoplasmic reticulum; endoplasmic reticulum stress; glioblastoma; Golgi complex; growth retardation; human; liver cell carcinoma; lung cancer; metastasis; myoclonus epilepsy; nerve degeneration; nerve fiber growth; neuroblastoma; neurologic disease; neuroprotection; nonhuman; Parkinson disease; pathogenesis; prognosis; prostate cancer; protein expression; protein folding; protein function; psychomotor retardation; review; schizophrenia; signal transduction; spinocerebellar degeneration; stomach carcinoma; ubiquitination; unfolded protein response; upregulationreview10.1016/S0929-6646(11)60064-82-s2.0-79960803788